There is a new titanium frame lock knife option on the market from an unlikely source. Maxpedition has introduced the limited edition EXCELSA knife and it has some very nice features for the price (compared to other Ti frame lock knives).
It features a 6Al4V Titanium alloy handle with frame lock and tip up or tip down, deep carry pocket clip. The drop point blade is flat ground from D2 tool steel and available in two sizes (2.9″ and 3.6″). It has ramped thumb studs and a mechanism that prevents lock bar overtravel.
Check out the EXCELSA from Maxpedition.